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You be the Judge: Understanding and Evaluating the Quality of Human Cryopreservations from Cryonics Organization Literature and Case Report Data, Part 3
By Mike Darwin In the narrowest sense, Standby does not begin until cryonics organization personnel are deployed on-site to care for the patient. However, elements of peri-arrest care, such as counseling the patient and family, beginning a program of premedication, … Continue reading
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Letter to the Aspirants
The following is an edited for publication version of a letter that has been written in various versions to various people over the past 5 years. This, the last version, was written in 2008. These letters always began Dear _________, … Continue reading
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Chronosphere is Not a Blog!
By Mike Darwin Some years ago, Aschwin de Wolf pushed me very hard to do a blog. We actually got to the point where, due to Aschwin’s efforts, the site was set up on WordPress, and I had done some … Continue reading
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The Pathophysiology of Ischemic Injury: Impact on the Human Cryopreservation Patient, Part 4
By Mike Darwin Intracellular Acidosis & Alkalosis While clearly not the sole, or even the major source of injury in ischemia, intracellular lactic acidosis does contribute to the pathophysiology of ischemia,173 Cortical lactate levels above a threshold of 18 – … Continue reading
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The Pathophysiology of Ischemic Injury: Impact on the Human Cryopreservation Patient, Part 3
By Mike Darwin Excitotoxicity A rapidly growing body of evidence indicates that excitatory neurotransmitters, primarily the excitatory amino acids (EEAs) aspartate, N-methyl-D-aspartate (NMDA), homocysteine and cysteine, which are released from neurons during ischemia, play an important role in the etiology … Continue reading
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The Pathophysiology of Ischemic Injury: Impact on the Human Cryopreservation Patient, Part 2
The Pathophysiology of IRI While a wide range of post-insult interventions are currently being investigated in animal and clinical trials, and despite almost universal agreement that CI is a multifactorial insult, there has been little or no research aimed at … Continue reading
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Welcome to a New World
I was cold and edgy. We had departed Mosul well before dawn, in order to arrive at Nineveh before the call to morning prayers. Mosul had been a jumble of box-like, recent construction; unimpressive Mosques and the grim and gritty dwellings of the poor. The drive had been the usual terrifying excursion into the pitch blackness of a moonless night, with only the infrequent and very momentary benefit of headlights. A burned out headlamp is a financial disaster in this part of the Arab world, so road travel proceeds at breakneck speed in complete darkness, with only brief flashes of the headlights to keep the driver in position on the road and from colliding, head-on, with any oncoming traffic. Continue reading
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