Category Archives: Ischemia-Reperfusion Injury

Last Aid as First Aid for Cryonicists, Part 2

To fix a problem you first have to understand that you have one. While all cryonicists understand the idea that time after cardiac arrest without cooling or other stabilization is not good, few can even describe this injury by its proper name; ischemic injury. Fewer still can provide even the barest details about its mechanics and time course, and only a handful of cryonicists would even be able to voice an opinion about at what point in this process they think such damage might become irreversible (short of complete decomposition). Almost none could give reasons as to what constitutes the basis for their opinion. This state of affairs is both unacceptable and dangerous. It is unacceptable because it has been 47 years since cryonics began, and during that time an enormous amount has been learned about the biological basis of personality and memory, and about ischemic injury and ways to reduce, if not eliminate it. Failing to act in the face of such knowledge is inexcusable. Continue reading

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Last Aid as First Aid for Cryonicists, Part 1

“Last Aid as First Aid for Cryonicists” is part of an ongoing series of articles that will published from time to time, to inform cryonicists of what they can do for themselves locally, to minimize ischemic injury in the event of cardiac arrest. Continue reading

Posted in Cryonics Technology (General), Ischemia-Reperfusion Injury | 2 Comments

The Lifebridge B2T® “Plug-and-Play” Extracorporeal Life Support System

By Mike Darwin Figure 1: The ultra-compact, lightweight and fully self contained Lifebridge B2T® Portable Extracorporeal Life Support System. Introduction The Medizintechnik GmbH Lifebridge B2T® extracorporeal life support system (Figure 1) is a device fast closing in on a technology … Continue reading

Posted in Cryonics Technology (General), Ischemia-Reperfusion Injury, Medicine, Perfusion | 3 Comments

Does Personal Identity Survive Cryopreservation?

By Mike Darwin Introduction Someone who wants to understand the critical technical, social, political or personal issues involved in cryonics may well turn to any of several FAQ’s (Frequently Asked Questions) sites hosted by the various cryonics organizations.[1],[2],[3] As someone … Continue reading

Posted in Cryobiology, Cryonics Philosophy, Cryonics Technology (General), Ischemia-Reperfusion Injury | 16 Comments

The Pathophysiology of Ischemic Injury: Impact on the Human Cryopreservation Patient, Part 1

“There are, at a minimum, five obstacles that must be overcome in order to allow the restoration of human cryopreservation patients to life and health:

1. Reversal of any ischemia or ischemia-reperfusion injury (IRI) suffered during the peri- and post-cardiac arrest intervals before definitive stabilization in the solid state can be undertaken.
2. Repair of injuries, gross, microscopic, ultramicroscopic and biochemical, secondary to the cryopreservation process.
3. Cure for the underlying pathology(ies) which caused the patient’s terminal illness.
4. Replacement of any missing or discarded tissues/organs resulting from medical interventions (i.e., amputation, excision, ablation) or from neuropreservation.
5. Control over and reversal of the aging process.

The implication of this is that where Human Cryopreservation Organizations (HCOs) can make the most difference for the least expenditure of resources is to focus their efforts on minimizing (and ultimately eliminating) the damage their patients suffer from ischemia-reperfusion injury (IRI), and from CPA perfusion and cooling to storage temperature (currently -196 ºC). While these may seem three discrete and unrelated problems they are in fact powerfully related.”

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